Microbiota ocular y Antibioterapia

La terapia con antibióticos es un tratamiento comúnmente utilizado para las infecciones oculares bacterianas.

Sin embargo, la terapia con antibióticos puede provocar una alteración de la microbiota ocular normal y un mayor riesgo de infecciones oculares recurrentes.

La prueba de microbiota ocular puede ayudar a identificar las bacterias responsables de las infecciones oculares y seleccionar el antibiótico más eficaz.

Además, la prueba puede ayudar a monitorear la efectividad del tratamiento con antibióticos e identificar a los pacientes en riesgo de infecciones oculares recurrentes.


Bibliografia:

  1. Willcox M, Zhu H, Knox K, et al. The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018;8(12):1432-1439. doi: 10.1002/alr.22244
  2. Doan T, Akileswaran L, Andersen D, et al. Paucity of evidence to support that abnormal microbiota composition is related to ocular disease. Microorganisms. 2020;8(3):425. doi: 10.3390/microorganisms8030425
  3. Romano V, Obregón-Guerrero G, et al. The effect of topical antibiotics on the conjunctival microbiota of patients undergoing intravitreal injections. Ophthalmology. 2017;124(6):816-824. doi: 10.1016/j.ophtha.2017.01.028
  4. Hua X, Yuan X, Tang X, et al. Effects of antibiotics on the microbiome of mice. Exp Ther Med. 2018;16(2):1306-1312. doi: 10.3892/etm.2018.6346
  5. Cevallos V, Upadhyay M, Whitcher J, et al. The relationship between the microbiome and ocular health. J Ophthalmol. 2018;2018:3130467. doi: 10.1155/2018/3130467
  6. McMahon T, Brereton M, Goldsmith C, et al. The effect of topical antibiotics on the conjunctival microbiome in patients with glaucoma. Ophthalmol Glaucoma. 2019;2(3):179-185. doi: 10.1016/j.ogla.2019.04.002
  7. Graham J, Moore J, Jiru X, et al. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci. 2007;48(12):5616-5623. doi: 10.1167/iovs.07-0560
  8. Den Beste K, Brown M, Holberts A, et al. The effect of topical antibiotics on the conjunctival flora of patients undergoing intravitreal injection. Retina. 2019;39(9):1769-1774. doi: 10.1097/IAE.0000000000002211
  9. Gadjeva M, Nagashima J, Zaidi T, et al. Effects of the microbiota on eye health. Am J Ophthalmol. 2016;171:17-22. doi: 10.1016/j.ajo.2016.07.019
  10. Tamhane A, Dunbar H, Miller P, et al. Prospective evaluation of the effect of antibiotics on the ocular microbiome. Am J Ophthalmol. 2021;226:93-101. doi: 10.1016/j.ajo.2020.12.029

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Tagged in: Ocular Dysbiosis


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