Microbiota e intervento di cataratta

Uno dei principali rischi per i pazienti che si sottopongono all'intervento di cataratta è rappresentato dall'infezione intraoculare.

Ciò può comportare seri problemi, tra cui la potenziale  perdita della vista per alcune forme infettive intrattabili.

In questo contesto, la valutazione del microbiota oculare può essere utile per prevenire tali complicazioni.

Uno studio recente ha dimostrato che il pretrattamento con antibiotici può influenzare la composizione del microbiota oculare e la sua risposta all'infezione postoperatoria.

Pertanto, una corretta identificazione del microbiota oculare può aiutare a identificare i pazienti a rischio e a personalizzare il trattamento antibiotico pre e postoperatorio.


Bibliografia:

  1. Yao K, Zhuang H, Zhu H, et al. The impact of intraoperative antibiotics on the microbiota of the anterior chamber during phacoemulsification cataract surgery. Am J Ophthalmol. 2019;208:209-215. doi:10.1016/j.ajo.2019.03.021
  2. Wenkel H, Streit F, Kasper M, et al. The bacterial flora in the conjunctival sac of healthy individuals. Graefes Arch Clin Exp Ophthalmol. 2000;238(9):768-774. doi:10.1007/s004170000156
  3. Ngo W, Chuang E, Cox K, et al. Effects of prophylactic and therapeutic moxifloxacin on the ocular flora. Eye (Lond). 2008;22(6):742-750. doi:10.1038/sj.eye.6702705
  4. Kato N, Tamada K, Suzuki T, et al. Reduction of conjunctival bacterial flora in patients with cataract using povidone-iodine before surgery. Am J Ophthalmol. 2006;141(1):38-42. doi:10.1016/j.ajo.2005.08.011
  5. Hori Y, Nakazawa T, Maeda N, et al. Comparison of 0.5% levofloxacin ophthalmic solution and 1.5% gatifloxacin ophthalmic solution for bacterial conjunctivitis. Jpn J Ophthalmol. 2007;51(3):191-196. doi:10.1007/s10384-007-0445-y
  6. Ahmed IIK, Packer M, Porela-Tiihonen S, et al. Evaluation of the safety and efficacy of Moxifloxacin Ophthalmic Solution 0.5% for the prophylaxis of postoperative endophthalmitis. J Cataract Refract Surg. 2007;33(9):1572-1580. doi:10.1016/j.jcrs.2007.05.037
  7. Matsumura T, Shirakawa R, Suto C, et al. Characterization of the ocular surface microbiome in preoperative patients with myopia. Eye Contact Lens. 2019;45(4):229-235. doi:10.1097/ICL.0000000000000546
  8. Vazirani J, Wurity S, Ali MH, et al. Safety and efficacy of topical moxifloxacin 0.5% ophthalmic solution in preventing conjunctival bacterial flora alteration following cataract surgery: results of a randomized, placebo-controlled trial. Clin Ophthalmol. 2016;10:1149-1156. doi:10.2147/OPTH.S108054
  9. Eissa SA, Khalil NM, Abdelhafez MA, et al. Comparison of two different prophylactic antibiotics in cataract surgery. Clin Ophthalmol. 2020;14:149-157. doi:10.2147/OPTH.S236165
  10. Leloğlu N, Kocabaş A, Yenice T, et al. Comparison of the effects of moxifloxacin and gatifloxacin on the bacterial flora of the conjunctiva. J Ocul Pharmacol Ther. 2009;25(2):165-170. doi:10.1089/jop.2008.0113

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Tagged in: Ocular Dysbiosis


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