Ocular microbiome and the healthy eye

The healthy eye microbiome is composed of a variety of microorganisms, including bacteria, viruses, fungi, and protozoa.

The composition of the ocular microbiome varies depending on the region of the eye considered and can be influenced by several factors, such as age, gender, diet and contact lens use.

The most common bacteria found in the healthy eye microbiome include Staphiloccoccus epiderm.

These bacteria are capable of producing antimicrobial compounds that help prevent colonization by potentially harmful pathogens.
In addition, the healthy ocular microbiome is characterized by high microbial diversity and a low concentration of pathogenic microorganisms.

The ocular microbiome plays an important role in protecting the eye from infection by external pathogens, regulating ocular inflammation, and producing tear film.

In addition, the healthy ocular microbiome has been associated with a lower risk of developing eye diseases such as dry eye syndrome.
Understanding the healthy ocular microbiome is important for the development of targeted therapies for eye diseases.


Bibliography:

  1. Shin H, Price K, Albert L, Dodick J, Park L, Dominguez-Bello MG. Changes in the Eye Microbiota Associated with Contact Lens Wearing. MBio. 2016;7(2):e00198-16. doi:10.1128/mBio.00198-16.
  2. Ozkan J, Nielsen S, Diez-Vives C, et al. Temporal Stability and Composition of the Ocular Surface Microbiome. Sci Rep. 2017;7(1):9880. doi:10.1038/s41598-017-10578-9.
  3. Lee SH, Oh DH, Jung JY, et al. Comparative Ocular Microbiome Study of Two Distinct Populations in Thailand and Japan. Sci Rep. 2018;8(1):9625. doi:10.1038/s41598-018-27736-4.
  4. Wen X, Miao L, Deng Y, Bible PW, Hu X, Zou Y. Evaluation of the Conjunctival Microbiome in Healthy Individuals. Eye Contact Lens. 2018;44 Suppl 2:S173-S178. doi:10.1097/ICL.0000000000000448.
  5. Doan T, Akileswaran L, Andersen D, et al. Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva. Invest Ophthalmol Vis Sci. 2016;57(13):5116-5126. doi:10.1167/iovs.16-20055.
  6. Huang Y, Yang B, Li W. Defining the normal core microbiome of conjunctival microbial communities. Clin Microbiol Infect. 2016;22(7):643.e7-643.e12. doi:10.1016/j.cmi.2016.02.017
  7. Willcox MDP, Zhao Y, Naduvilath T, et al. The ocular surface microbiota in health and disease. Front Biosci (Landmark Ed). 2018;23:1495-1509. doi:10.2741/4664
  8. Ozkan J, Willcox M, Wemheuer B, Wilcsek G, Coroneo M, Thomas T. Biogeography of the human ocular microbiota. Ocul Surf. 2019;17(1):111-118. doi:10.1016/j.jtos.2018.10.001
  9. Doan T, Akileswaran L, Andersen D, et al. Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva. Invest Ophthalmol Vis Sci. 2016;57(13):5116-5126. doi:10.1167/iovs.16-20041
  10. Zhou Y, Holland MJ, Makalo P, et al. The conjunctival microbiome in health and trachomatous disease: a case control study. Genome Med. 2014;6(11):99. doi:10.1186/s13073-014-0099-0

Published on

Tagged in: Ocular Dysbiosis


Related articles
🇬🇧
🇮🇹
🇪🇸
LUCY does not claim to diagnose, treat, cure, or prevent any disease. The information on the LUCY website is provided for informational purposes only and with the understanding that LUCY is not engaged in rendering medical advice or recommendations. You should not rely on any information on the website to diagnose or treat a health problem or condition or replace consultations with qualified health care professionals to meet your individual needs. Always check with your doctor for answers to your personal medical questions.

Copyright © 2022 Eyemetagenomics Ltd. All rights reserved.
Cookie Policy