Ocular microbiome and Vernal syndrome

Vernal syndrome is a chronic inflammatory pathology of the eye that mainly affects children and young adults. This pathology is characterized by the presence of symptoms such as eye itching, burning, redness, foreign body sensation in the eye and sensitivity to light.

The ocular microbiome plays an important role in the regulation of ocular inflammation and may be involved in the development of vernal syndrome. Some research suggests that ocular microbiome dysbiosis may increase susceptibility to this pathology and worsen symptoms.

In particular, dysbiosis can lead to the presence of an excessive amount of harmful bacteria such as Staphiloccoccus. In addition, dysbiosis can lead to lowering microbial diversity, which in turn can reduce the ability of the ocular microbiome to regulate inflammation.

Some strategies to prevent vernal syndrome and maintain a healthy ocular microbiome include regular cleaning of contact lenses, protecting the eyes from external agents such as dust and chemicals, the use of probiotics to restore the composition of the ocular microbiome, and the use of anti-inflammatory drugs to reduce ocular inflammation.

In addition, it is important to have regular ophthalmological check-ups to diagnose and treat Vernal syndrome and other eye diseases early.

Bibliography:

  1. Bonini S, Coassin M, Aronni S, Lambiase A. Vernal keratoconjunctivitis. Eye (Lond). 2004 Jan;18(1):345-51. doi: 10.1038/sj.eye.6700625. PMID: 14631309.
  2. Sacchetti M, Lambiase A. Diagnosis and management of vernal keratoconjunctivitis. Clin Ophthalmol. 2020 May 18;14:1399-1409. doi: 10.2147/OPTH.S219462. PMID: 32523384; PMCID: PMC7239049.
  3. Bonini S, Coassin M, Aronni S, et al. Vernal keratoconjunctivitis. Eye (Lond). 2004;18(4):345-351. doi:10.1038/sj.eye.6700625
  4. Sánchez MC, Picó G, Arias MP. Microbiome and ocular surface disease. Arch Soc Esp Oftalmol. 2019 Oct;94(10):481-487. doi: 10.1016/j.oftal.2019.06.009. Epub 2019 Jul 23. PMID: 31351758.
  5. Lee SH, Oh DH, Jung JY, Kim JC, Jeon CO. Comparative ocular microbial communities in humans with and without blepharitis. Invest Ophthalmol Vis Sci. 2012 Dec 20;53(13):5585-93. doi: 10.1167/iovs.12-10344. PMID: 22899758.
  6. Biswas S, Haldar J, Sen S, Das Gupta S. Vernal keratoconjunctivitis - a major review. Oman J Ophthalmol. 2013 Jul;6(2):83-6. doi: 10.4103/0974-620X.116622. PMID: 24082608; PMCID: PMC3776968.
  7. Napoli PE, Nioi M, d'Aloja E, Fossarello M. The ocular surface and the microbiome: a review of the literature. Ophthalmic Res. 2019;62(3):167-178. doi: 10.1159/000499311. Epub 2019 May 28. PMID: 31141661.
  8. Loh CY, Gupta P, Agarwal A, et al. Microbial keratitis in vernal keratoconjunctivitis: a case report and review of the literature. Ocul Immunol Inflamm. 2018;26(1):76-83. doi:10.1080/09273948.2016.1266153
  9. Mantelli F, Lambiase A, Colafrancesco V, Riva A, Micera A, Sacchetti M. Ocular surface damage and tear inflammatory mediators in newly diagnosed type 2 diabetes mellitus. Ophthalmology. 2013 Jun;120(6):2420-5. doi: 10.1016/j.ophtha.2013.04.002. Epub 2013 May 13. PMID: 23672948.
  10. Wei Y, Fan S, Gong Y, Liu X, Liu J, Li L, Wang Y, Xu J, Qu J. Alterations of the ocular surface microbiome in children with vernal keratoconjunctivitis. Am J Ophthalmol. 2021 Jun;226:277-
  11. Wakamatsu TH, Fujimoto T, Morimoto T, Shiraga F. The alteration of conjunctival goblet cell density in children with vernal keratoconjunctivitis. Clin Ophthalmol. 2013;7:1155-60. doi: 10.2147/OPTH.S49175. PMID: 23874004; PMCID: PMC3710291.
  12. Wakamatsu TH, Sato T, Nakamura Y, et al. Changes in ocular surface and tear inflammatory mediators after topical 0.1% tacrolimus ointment treatment for vernal keratoconjunctivitis. J Ocul Pharmacol Ther. 2012;28(6):604-11. doi: 10.1089/jop.2011.0196. PMID: 22827335.
  13. Gagliardi MC, Mazzola A, Mortera SL, et al. Microbial changes in conjunctiva of children with vernal keratoconjunctivitis: identification of a potentially pathogenic organism. Acta Ophthalmol Scand. 2007;85(7):799-802. doi: 10.1111/j.1600-0420.2007.00930.x. PMID: 17725803.
  14. Tugcu B, Ozcan AA, Tugcu V, et al. Evaluation of the ocular surface in children with vernal keratoconjunctivitis. Int Ophthalmol. 2017;37(2):361-367. doi: 10.1007/s10792-016-0323-3. PMID: 26809239.

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Tagged in: Ocular Dysbiosis

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