Ocular microbiota and antibiotic therapy

Antibiotic therapy is a commonly used treatment for bacterial eye infections.

However, antibiotic therapy may result in an alteration of the normal ocular microbiota and an increased risk of recurrent ocular infections.

The ocular microbiota test can help identify the bacteria responsible for eye infections and select the most effective antibiotic.

In addition, the test can help monitor the effectiveness of antibiotic treatment and identify patients at risk for recurrent eye infections.


  1. Willcox M, Zhu H, Knox K, et al. The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018;8(12):1432-1439. doi: 10.1002/alr.22244
  2. Doan T, Akileswaran L, Andersen D, et al. Paucity of evidence to support that abnormal microbiota composition is related to ocular disease. Microorganisms. 2020;8(3):425. doi: 10.3390/microorganisms8030425
  3. Romano V, Obregรณn-Guerrero G, et al. The effect of topical antibiotics on the conjunctival microbiota of patients undergoing intravitreal injections. Ophthalmology. 2017;124(6):816-824. doi: 10.1016/j.ophtha.2017.01.028
  4. Hua X, Yuan X, Tang X, et al. Effects of antibiotics on the microbiome of mice. Exp Ther Med. 2018;16(2):1306-1312. doi: 10.3892/etm.2018.6346
  5. Cevallos V, Upadhyay M, Whitcher J, et al. The relationship between the microbiome and ocular health. J Ophthalmol. 2018;2018:3130467. doi: 10.1155/2018/3130467
  6. McMahon T, Brereton M, Goldsmith C, et al. The effect of topical antibiotics on the conjunctival microbiome in patients with glaucoma. Ophthalmol Glaucoma. 2019;2(3):179-185. doi: 10.1016/j.ogla.2019.04.002
  7. Graham J, Moore J, Jiru X, et al. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci. 2007;48(12):5616-5623. doi: 10.1167/iovs.07-0560
  8. Den Beste K, Brown M, Holberts A, et al. The effect of topical antibiotics on the conjunctival flora of patients undergoing intravitreal injection. Retina. 2019;39(9):1769-1774. doi: 10.1097/IAE.0000000000002211
  9. Gadjeva M, Nagashima J, Zaidi T, et al. Effects of the microbiota on eye health. Am J Ophthalmol. 2016;171:17-22. doi: 10.1016/j.ajo.2016.07.019
  10. Tamhane A, Dunbar H, Miller P, et al. Prospective evaluation of the effect of antibiotics on the ocular microbiome. Am J Ophthalmol. 2021;226:93-101. doi: 10.1016/j.ajo.2020.12.029

Published on

Tagged in: Ocular Dysbiosis

Related articles
Eyemetagenomics Ltd
71-75 Shelton Street, Covent Garden
LUCY does not claim to diagnose, treat, cure, or prevent any disease. The information on the LUCY website is provided for informational purposes only and with the understanding that LUCY is not engaged in rendering medical advice or recommendations. You should not rely on any information on the website to diagnose or treat a health problem or condition or replace consultations with qualified health care professionals to meet your individual needs. Always check with your doctor for answers to your personal medical questions.

Copyright ยฉ 2024 Eyemetagenomics Ltd. All rights reserved.
Cookie Policy