Ocular microbiota and cataract surgery

One of the main risks for patients undergoing cataract surgery is intraocular infection.

This can lead to serious problems, including loss of vision.

In this context, evaluation of the ocular microbiota may be useful to prevent such complications.

A recent study has shown that pretreatment with antibiotics can affect the composition of the ocular microbiota and its response to postoperative infection.

Therefore, proper identification of the ocular microbiota can help identify patients at risk and personalize pre-and post-operative antibiotic treatment.


  1. Yao K, Zhuang H, Zhu H, et al. The impact of intraoperative antibiotics on the microbiota of the anterior chamber during phacoemulsification cataract surgery. Am J Ophthalmol. 2019;208:209-215. doi:10.1016/j.ajo.2019.03.021
  2. Wenkel H, Streit F, Kasper M, et al. The bacterial flora in the conjunctival sac of healthy individuals. Graefes Arch Clin Exp Ophthalmol. 2000;238(9):768-774. doi:10.1007/s004170000156
  3. Ngo W, Chuang E, Cox K, et al. Effects of prophylactic and therapeutic moxifloxacin on the ocular flora. Eye (Lond). 2008;22(6):742-750. doi:10.1038/sj.eye.6702705
  4. Kato N, Tamada K, Suzuki T, et al. Reduction of conjunctival bacterial flora in patients with cataract using povidone-iodine before surgery. Am J Ophthalmol. 2006;141(1):38-42. doi:10.1016/j.ajo.2005.08.011
  5. Hori Y, Nakazawa T, Maeda N, et al. Comparison of 0.5% levofloxacin ophthalmic solution and 1.5% gatifloxacin ophthalmic solution for bacterial conjunctivitis. Jpn J Ophthalmol. 2007;51(3):191-196. doi:10.1007/s10384-007-0445-y
  6. Ahmed IIK, Packer M, Porela-Tiihonen S, et al. Evaluation of the safety and efficacy of Moxifloxacin Ophthalmic Solution 0.5% for the prophylaxis of postoperative endophthalmitis. J Cataract Refract Surg. 2007;33(9):1572-1580. doi:10.1016/j.jcrs.2007.05.037
  7. Matsumura T, Shirakawa R, Suto C, et al. Characterization of the ocular surface microbiome in preoperative patients with myopia. Eye Contact Lens. 2019;45(4):229-235. doi:10.1097/ICL.0000000000000546
  8. Vazirani J, Wurity S, Ali MH, et al. Safety and efficacy of topical moxifloxacin 0.5% ophthalmic solution in preventing conjunctival bacterial flora alteration following cataract surgery: results of a randomized, placebo-controlled trial. Clin Ophthalmol. 2016;10:1149-1156. doi:10.2147/OPTH.S108054
  9. Eissa SA, Khalil NM, Abdelhafez MA, et al. Comparison of two different prophylactic antibiotics in cataract surgery. Clin Ophthalmol. 2020;14:149-157. doi:10.2147/OPTH.S236165
  10. Leloğlu N, Kocabaş A, Yenice T, et al. Comparison of the effects of moxifloxacin and gatifloxacin on the bacterial flora of the conjunctiva. J Ocul Pharmacol Ther. 2009;25(2):165-170. doi:10.1089/jop.2008.0113

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Tagged in: Ocular Dysbiosis

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