Ocular microbiota and immune system

Studies on the ocular microbiota have shown the presence of a wide range of bacterial species, some of which may have a protective role against certain eye diseases.

In particular, the interaction between the ocular microbiota and the host immune system appears to play a key role in regulating the local inflammatory response, through the production of pro - and anti-inflammatory interleukins.

Some research suggests that the ocular microbiota may influence the production of interleukin-17 (IL-17), which plays an important role in innate immunity against certain bacterial infections.

Similarly, some bacterial species of the ocular microbiota appear to be able to modulate the production of interleukin-10 (IL-10), an anti-inflammatory cytokine that plays an important role in preventing excessive immune response that could damage eye tissues.


Bibliography:

  1. Huang Y, Yang B, Li W. Defining the normal core microbiome of conjunctival microbial communities. Clin Microbiol Infect. 2016 Apr;22(4):335.e1-8. doi: 10.1016/j.cmi.2015.12.010. Epub 2016 Jan 7. PMID: 26773358.
  2. Lu LJ, Liu J. Human Microbiota and Ophthalmic Disease. Yale J Biol Med. 2016 Dec 15;89(4):325-330. PMID: 28018147; PMCID: PMC5153240.
  3. Willcox MD, Zhu H, Knox KW. Streptococcus pneumoniae (pneumococcus) adherence to the human conjunctival epithelial cells and acanthamoeba castellanii. Clin Exp Optom. 2000 Mar;83(2):73-8. doi: 10.1111/j.1444-0938.2000.tb04824.x. PMID: 15982736.
  4. Redfern RL, McDermott AM. Toll-like receptors in ocular surface disease. Exp Eye Res. 2010 Dec;90(1):679-87. doi: 10.1016/j.exer.2010.01.022. Epub 2010 Jan 29. PMID: 20116456; PMCID: PMC2893089.
  5. Lee SH, Oh DH, Jung JY, Kim JC, Jeon CO. Comparative ocular microbial communities in humans with and without blepharitis. Invest Ophthalmol Vis Sci. 2012 Apr 20;53(4):5585-93. doi: 10.1167/iovs.12-10134. PMID: 22736620.
  6. Eguchi H, Hotta F, Kuwana M. Possible involvement of bacteria in the pathogenesis of IgG4-related ophthalmic disease. Ocul Immunol Inflamm. 2015 Feb;23(1):65-71. doi: 10.3109/09273948.2014.883561. Epub 2014 Mar 4. PMID: 24580587.
  7. Devaraj S, Cheung G, Park JH, Mak JY, Maslin K, Yeung S, Fan NW, Hsiao CH, Chu KO, Chong KK, Yuen HK, Chan TC, Ng AL, Lai TY, Tham CC, Cheung CM. Association of Ocular Microbiota and Clinical Outcomes in Ocular Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017 Mar;23(3):425-435. doi: 10.1016/j.bbmt.2016.11.013. Epub 2016 Nov 16. PMID: 27864089.
  8. Ling Z, Liu X, Cheng Y, Jiang X, Jiang H, Wang Y, Li L, Xiang C. Decreased diversity of the ocular surface microbiome in myopia. Exp Eye Res. 2020 Aug;197:108116. doi: 10.1016/j.exer.2020.108116. Epub 2020 Jun 20. PMID: 32574667.
  9. Lee YB, Lee S, Lee HJ, Yu HG, Kang SW, Seo KY. Comparison of conjunctival microbial flora in healthy individuals with those with allergic conjunctivitis or vernal keratoconjunctivitis. Clin Exp Ophthalmol. 2016 Dec;44(9):778-786.
  10. Ozkan J, Nielsen S, Diez-Vives C, et al. Temporal Stability and Composition of the Ocular Surface Microbiome. Sci Rep. 2017;7(1):9880. doi:10.1038/s41598-017-10487-9
  11. de Paiva CS, Jones DB, Stern ME, et al. Altered Mucosal Microbiome Diversity and Disease Severity in Sjรถgren Syndrome. Sci Rep. 2016;6:23561. doi:10.1038/srep23561
  12. Huang Y, Yang B, Li W. Defining the normal core microbiome of conjunctival microbial communities. Clin Microbiol Infect. 2016;22(7):643.e7-643.e12. doi:10.1016/j.cmi.2016.03.018
  13. Zaidi T, Zaidi T, Cywes-Bentley C, et al. Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye. Sci Rep. 2017;7(1):14407. doi:10.1038/s41598-017-13977-1
  14. Ramesh A, Kasetti RB, Joseph J, et al. Alterations in Tear Fluid TGF-ฮฒ and IL-6 Levels Following Cataract Surgery. Ocul Immunol Inflamm. 2018;26(8):1223-1229. doi:10.1080/09273948.2017.1413945
  15. Shi X, Zhang Y, Chen Y, et al. Interleukin-33 promotes inflammation-induced lymphangiogenesis via ST2/TRAF6-mediated Akt/eNOS/NO signalling pathway. Sci Rep. 2017;7(1):10602. doi:10.1038/s41598-017-10950-5
  16. Wang Y, Jia L, Yuan L, et al. A preliminary study on the changes of tear cytokines and conjunctival microorganisms after phacoemulsification in age-related cataract patients. Sci Rep. 2017;7:42128. doi:10.1038/srep42128
  17. El-Ganiny AM, Ali SA, El-Badry AA, et al. Impact of Aspergillus fumigatus on IL-33-Dependent Conjunctival Stromal Cells in Chronic Allergic Conjunctivitis. Invest Ophthalmol Vis Sci. 2019;60(12):3917-3926. doi:10.1167/iovs.19-27515
  18. Kumar S, Patel S, Shahane A. Interleukin-17 levels in tear samples of patients with dry eye disease from India. Ocul Immunol Inflamm. 2019;27(1):27-33. doi:10.1080/09273948.2017.1391458
  19. Sun Y, Peng Y, Han Z, et al. Interleukin-17A as a Potential Diagnostic Marker for Ocular Behcet's Disease. Ocul Immunol Inflamm. 2019;27(2):237-245. doi:10.1080/09273948.2017.1378729

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