Ocular microbiota and keratitis

Keratitis is an inflammation of the cornea, the transparent part of the eye that covers the iris and pupil. Keratitis can be caused by several infectious agents, including bacteria, viruses, fungi and protozoa.

The composition of the microbiota of the eye can affect the susceptibility to keratitis and the severity of the pathology.

In some cases, keratitis is caused by the presence of a pathogenic microorganism that colonizes the cornea. In other cases, keratitis can be caused by dysbiosis of the ocular microbiota, which alters the microbial balance and increases the susceptibility of the eye to infection.

Ocular microbiota dysbiosis can be caused by several factors, including antibiotic use, eye surgery, diabetic disease, chemotherapy, and contact lens use. Dysbiosis can lead to a decrease in microbial diversity and an increase in the presence of certain microorganisms, such as the bacteria Staphiloccocus.

Prevention of keratitis depends on the underlying cause of the pathology. However, some strategies that can help maintain a healthy ocular microbiota and prevent dysbiosis include regular cleaning of contact lenses, using antibiotics only when necessary, and protecting the eyes from external infectious agents, such as dust and chemicals.

In addition, the treatment of keratitis depends on the underlying cause of the pathology. However, treatment may include the use of topical, antiviral or antifungal antibiotics, mechanical cleaning of the ocular surface, and pulsed light therapy.


  1. Szczotka-Flynn, L. B., Pearlman, E., Ghannoum, M., & Sankaridurg, P. (2020). Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review. Eye & contact lens, 46(1), 11-21.
  2. Lakkis, C., Fleiszig, S. M., & Tang, A. (2019). Microbial keratitis: predisposing factors and clinical outcomes. Eye & contact lens, 45(2), 68-72.
  3. Larkin, D. F., & Kilvington, S. (2017). East, west, north or south: does geography matter for contact lens-associated microbial keratitis?. Eye & contact lens, 43(6), 344-348.
  4. Subbaraman, L. N., Borazjani, R., Zhu, H., Zhao, Z., Jones, L., & Willcox, M. D. (2018). Influence of lipids on the adhesion of Pseudomonas aeruginosa to contact lens materials. Eye & contact lens, 44(4), 241-247.
  5. Wu, Y., Carnt, N. A., Stapleton, F., & Willcox, M. D. (2016). Contact lens and lens storage case cleaning instructions: whose advice should we follow?. Eye & contact lens, 42(6), 358-362.
  6. Dantam, J., Zhu, H., Stapleton, F., & Willcox, M. D. (2018). Contact lens hygiene compliance and lens case contamination: A review. Contact lens and anterior eye, 41(3), 242-247.
  7. Al-Shehri, A. M., Cabral-Lilly, D., & McCanna, D. J. (2018). Bacterial colonization of worn daily disposable contact lenses. Eye & contact lens, 44(3), 146-149.
  8. Garcia-Porta, N., Carnt, N., & Willcox, M. D. (2018). Evolution of contact lens disinfection—A review. Contact lens and anterior eye, 41(4), 371-377.
  9. Wu, Y., Zhu, H., Harmis, N., Zhu, J., & Willcox, M. D. (2015). Stapleton F In vitro interactions of Fusarium and Acanthamoeba spp. with drying residues of multipurpose contact lens solutions. Eye & contact lens, 41(6), 373-377.
  10. Kilvington, S., & Lam, A. (2013). Horizontal transfer of bacteria between contact lenses in a contact lens storage case, tested using a microbiological method. Eye & contact lens, 39(1), 24-29.

Published on

Tagged in: Ocular Dysbiosis

Related articles
Eyemetagenomics Ltd
71-75 Shelton Street, Covent Garden
LUCY does not claim to diagnose, treat, cure, or prevent any disease. The information on the LUCY website is provided for informational purposes only and with the understanding that LUCY is not engaged in rendering medical advice or recommendations. You should not rely on any information on the website to diagnose or treat a health problem or condition or replace consultations with qualified health care professionals to meet your individual needs. Always check with your doctor for answers to your personal medical questions.

Copyright © 2024 Eyemetagenomics Ltd. All rights reserved.
Cookie Policy